Canine Tumor Genome Atlas Maps DNA in Pets to Help People with Cancer
Cancer center’s latest comparative oncology research leads to creation of genomic data warehouse
Pioneering work in comparative oncology continues at UC Davis with the launch of a Canine Tumor Genome Atlas, the first genomic data bank of its kind outside of one developed by the National Cancer Institute. Eventually it may store hundreds of gene samples from companion dogs diagnosed with osteosarcomas, oral melanomas and gliomas.
These three cancers are remarkably similar to the same cancers found in humans and, sadly, they can be uniformly fatal in both species. Through comparative oncology, scientists seek to find cures that work in dogs in the hope that similar therapies may work in people. In fact, canine clinical trials are underway at UC Davis to test an immunotherapy agent to fight cancer.
As part of its joint cancer research with the UC Davis School of Veterinary Medicine, UC Davis Comprehensive Cancer Center is building an extensive genome catalog in order to map why certain canines are genetically predisposed to cancer. Researchers hope that by helping find cures for pets with cancer, the atlas may also unlock similar breakthroughs for people with cancer.